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KMID : 0361020230660020127
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Korean Journal of Otolaryngology - Head and Neck Surgery
2023 Volume.66 No. 2 p.127 ~ p.130
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Hyalinizing Clear Cell Carcinoma of the Base of Tongue Mistaken for Benign Lesion: A Case Report
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Kim Min-Gyu
Heo Da-Beom
Moon Seong-Jun
Koo Bon-Seok
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Abstract
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Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade malignant tumor of the salivarygland. It usually originates from the minor salivary gland, with the most common site being thepalate, followed by the lips and the buccal mucosa. The occurrence of HCCC at the base of thetongue (BOT) is extremely uncommon, thus it must be differentiated from other malignantclear cell tumors. Immunohistochemistry is a useful tool to make an appropriate diagnosis. Toobtain the best prognosis for HCCC, complete surgical resection is necessary. Here we reporta case of a 47-year-old male with a benign-looking neoplasm in the right BOT, presenting withthroat discomfort. A simple excisional biopsy revealed proliferative nests of clear cells withina hyalinized fibrous connective tissue. The final diagnosis by immunohistochemistry wasHCCC with a positive resection margin. Re-operation secured a safety margin, and the lesionwas completely resected.
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KEYWORD
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Clear cell adenocarcinoma, Hyalin, Salivary gland, minor, Tongue neoplasm
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